The Women's Interagency HIV Study (WIHS)
Summary
The NYC/Bronx WIHS Consortium represents the highly successful collaboration of clinical and basic scientists at six New York institutions: Montefiore, Mount Sinai, and Beth Israel Medical Centers; Bronx Lebanon Hospital Center, The Wadsworth Research Center of the New York State Department of Health, and the Albert Einstein College of Medicine. The NYC/Bronx WIHS Consortium is one of six sites nationally conducting the Women's Interagency HIV Study (WIHS), an observational cohort study of 2055 HIV infected and 569 HIV uninfected women, investigating the natural history of HIV infection in women, including clinical, virologic, immunologic, behavioral and health care utilization parameters. The NYC/Bronx consortium has the largest number of retained WIHS subjects in active follow-up, and contributes approximately 24 percent of the core visit data. The NYC/Bronx consortium has made substantial contributions to the development of the WIHS scientific agenda, particularly in the areas of quantitative and molecular virology and in general disease progression, and to the development and support of the national WIHS administrative infrastructure. We seek to continue the core scientific activities of WIHS including delineating the relationship of HIV disease progression and mortality to viral burden, absolute and proportional CD4 cell counts, coinfections and behavioral parameters including compliance with therapy. Continuing investigation will also include determining the gynecologic manifestations of HIV disease, including the expression and sequelae of genital infection with human papillomavirus both at baseline and in the presence of highly active antiretroviral therapy (HAART). In addition we will continue our substudy of "Complete HIV-1 RNA sequences in women: CVL and plasma" through Dr. Barbara Weiser at the Wadsworth Center, the Research Laboratory of the New York State Department of Health. We also seek to expand both the local (NYC) and national WIHS scientific agenda to include determining the impact of HAART on disease progression, viral burden, HIV related morbidity and survival, as well as additional virologic, immunologic and behavioral investigations.
| Principal Investigator | Kathryn M Anastos |
| Co-Principal Investigator(s) | |
| Recipient Organization | MONTEFIORE MEDICAL CENTER (BRONX, NY) |
| Granting Organization | National Institute of Allergy and Infectious Diseases Extramural Activities(NIAID) |
| Reference | Dates | Fiscal Year | Funded Amount |
|---|---|---|---|
| 0 |
AIDS | AIDS related neoplasm /cancer | AIDS therapy | HIV infection | antiAIDS agent | female | female reproductive system disorder | female reproductive system neoplasm | human immunodeficiency virus 1 | human therapy evaluation | pathologic process | social behavior | Candida | Chlamydia | Kaposi\'s sarcoma | Treponema pallidum | Trichomonas | clinical trial phase II /III /IV | cooperative study | cytokine receptor | depression | disease /disorder proneness /risk | drug abuse | drug resistance | endocrine disorder | health care service utilization | hepatitis C virus | human T cell lymphotropic virus type 1 | human T cell lymphotropic virus type 2 | human herpesvirus 8 | human papillomavirus | leukocyte activation /transformation | menstrual cycle | pelvic inflammatory disease | pregnancy | sex behavior | sexually transmitted disease | smoking cessation | socioeconomics | therapy compliance | zidovudine | behavioral /social science research tag | clinical research | human subject | women\'s health
The following semantic terms have been automatically assigned to this grant. Terms are displayed in order of relevant type semantic type
| Ontology | Type | Term |
|---|---|---|
| umls | Activity | Collaboration |
| umls | Behavior | Visit |
| umls | Biomedical Occupation or Discipline | Molecular Virology |
| umls | Biomedical Occupation or Discipline | Medicine |
| umls | Body Substance | Plasma |
| umls | Classification | Research Infrastructure |
| umls | Disease or Syndrome | Genital infection |
| umls | Disease or Syndrome | HIV Infections |
| umls | Finding | Viral Load result |
| umls | Finding | Sequela of disorder |
| umls | Geographic Area | Lebanon |
| umls | Geographic Area | New York (geographic location) |
| umls | Geographic Area | Israel |
| umls | Health Care Activity | follow-up |
| umls | Health Care Activity | health care utilization |
| umls | Health Care Related Organization | Medical center |
| umls | Health Care Related Organization | Hospitals |
| umls | Individual Behavior | Behavior |
| umls | Laboratory Procedure | CD4 Count determination procedure |
| umls | Manufactured Object | research organization |
| umls | Manufactured Object | College |
| umls | Medical Device | Mounts |
| umls | Nucleic Acid, Nucleoside, or Nucleotide | RNA Sequence |
| umls | Pathologic Function | sequelae aspects |
| umls | Pathologic Function | Disease Progression |
| umls | Population Group | Woman |
| umls | Professional or Occupational Group | Consortium or Network |
| umls | Professional or Occupational Group | Scientist |
| umls | Qualitative Concept | Relationships |
| umls | Qualitative Concept | Absolute |
| umls | Qualitative Concept | Clinical |
| umls | Quantitative Concept | Cohort Studies |
| umls | Quantitative Concept | Percent (qualifier value) |
| umls | Research Activity | Laboratory Research |
| umls | Spatial Concept | Local |
| umls | Spatial Concept | Gynecologic |
| umls | Spatial Concept | Core |
| umls | Therapeutic or Preventive Procedure | behavioral health care |
| umls | Therapeutic or Preventive Procedure | Antiretroviral Therapy, Highly Active |
| umls | Virus | Human Papillomavirus |
| umls | Virus | HIV |
| umls | Virus | HIV-1 |