RCID: 654582
Link to this profile: http://www.researchcrossroads.org/Researchers/654582
Deborah J Anderson
BOSTON UNIVERSITY MEDICAL CAMPUS| Position Professor Department Environmental Health Degrees B.A., M.S., Ph.D. Interests Reproductive Biology, Sexually Transmitted Infections, Mucosal Immunology of the Human Genital Tract All Funding $ 12,513,050 |  |
Biography
| Education:
Rice University B.A. 1971 University of Texas GSBS Ph.D. 1976 Oregon Health Sciences Center Postdoc 1976-1980 Harvard Medical School Postdoc 1980-1982 Professional Positions: 1982 -1983 Instructor in Pathology, Harvard Medical School and Dana Farber Cancer Institute, Boston, MA 1983 -1985 Assist. Prof. in Pathology, Harvard Medical School and Dana Farber Cancer Inst., Boston, MA 1985 -1986 Assist. Prof. of Ob/Gyn, Harvard Medical School, Boston, MA 1985 -2004 Director, Fearing Laboratory, Brigham and Women's Hospital, Boston, MA 1986 -2004 Associate Professor of Ob/Gyn, Harvard Medical School, Boston, MA 2004– pres Lecturer, Department of Medicine, Harvard Medical School 2004- pres Professor of Ob/Gyn and Microbiology, Boston University Medical School Honors: Westinghouse Science Scholarship (1967-1969) Rosalie Hite Cancer Fellowship (1974-1976) Alexander Von Humboldt Research Award (1990) AFS Prize Paper Award (1990, 2001) AGOS Charles Hunter Award (1991) Ob/Gyn Resident's Teaching Award (1991) Thomas Hoope Prize for Teaching (1992) ASA Buckeye Award (1996) President’s Achievement Award, Society of Gynecologic Investigation (1998): Distinguished Alumnus Award, University of Texas Graduate School of Biomedical Sciences (2001) Member, National and International Public Advisory Committees WHO Steering Committee on Vaccines for Fertility Regulation (1985-1990) Chairman, WHO Sperm Antigen Workshops I-III (1986-1992) WHO Subcommittee of the Americas (1991-pres) TAC, Family Health International (1988-2000) NIH Reviewers' Reserve 1985-present: ad hoc reviewer for Immunology, HIV/AIDS and Reproductive Biology Study Sections 1996-2004: Member NIH AARR-6/ACE Study Section. |
Grants (Principal Investigator)
Grants for which Deborah J Anderson acted as the principal investigator
| Title/Granting Organization | Fiscal Years | Total Funding | |
|---|---|---|---|
| An In Vitro Model Of Cell-associated Hiv-1 Transmission | |||
| National Institute of Child Health & Human Development(NICHD) | 2006 - 2009 | $ 1,274,137 | |
| Seminal Hiv-1 Shedding And Drug Resistance In Hiv-1/hsv-2 Coinfected Men On Haart | |||
| National Institute of Allergy and Infectious Diseases Extramural Activities(NIAID) | 2007 - 2009 | $ 846,994 | |
| Effects Of Stds On Hiv Immunity And Infectivity In Semen | |||
| National Institute of Diabetes and Digestive and Kidney Diseases | 2005 | $ 80,750 | |
| Immunity To Stds In The Human Male Genital Tract | |||
| National Institute of Allergy and Infectious Diseases Extramural Activities(NIAID) | 2000 - 2004 | $ 4,011,761 | |
| Acquired Immunity To Std's In Male Genital Tract | |||
| National Institute of Allergy and Infectious Diseases Extramural Activities(NIAID) | 2000 - 2004 | ||
| Hiv 1 Immunity In The Human Male Urogenital Tract | |||
| National Institute of Allergy and Infectious Diseases Extramural Activities(NIAID) | 1998 - 2003 | $ 1,430,488 | |
| Uptake Of Ig By Vaginal Epithelial Cells | |||
| National Institute of Allergy and Infectious Diseases Extramural Activities(NIAID) | 1999 - 2003 | ||
| Factors Affecting Vaginal Immunity And Hiv Infection | |||
| Fogarty International Center(FIC) | 1999 - 2001 | $ 117,870 | |
| Male Genital Tract Inflammation And Hiv Transmission | |||
| National Institute of Child Health & Human Development(NICHD) | 1995 - 1999 | $ 1,597,174 | |
| Factors Affecting Vaginal Immunology And Hiv 1 Infection | |||
| National Institute of Child Health & Human Development(NICHD) | 1995 - 1998 | $ 1,386,749 | |
| Hiv Cellular Immunity In The Human Male Urogenital Tract | |||
| National Institute of Allergy and Infectious Diseases Extramural Activities(NIAID) | 1994 - 1997 | $ 1,147,038 | |
| Semen Cofactors In The Transmission Of Hiv-1 | |||
| National Institute of Allergy and Infectious Diseases Extramural Activities(NIAID) | 1994 | $ 207,208 | |
| Semen Cofactors In The Transmission Of Hiv 1 | |||
| National Institute of Allergy and Infectious Diseases Extramural Activities(NIAID) | 1992 - 1993 | $ 412,881 | |
| Semen Cofactors In The Transmission Of Aids | |||
| National Institute of Allergy and Infectious Diseases Extramural Activities(NIAID) | 1987 - 1989 | ||
| Cellular Immune Mechanisms In Infertility | |||
| National Institute of Child Health & Human Development(NICHD) | 1987 - 1989 | ||
| Autoimmunity To Testicular Germ Cell Oncofetal Antigens | |||
| National Cancer Institute(NCI) | 1984 - 1987 | ||
| Role Of Semen In Acquired Immunodeficiency Syndrome | |||
| National Institute of Allergy and Infectious Diseases Extramural Activities(NIAID) | 1984 - 1985 | ||
| Role Of Semen Inacquired Immunodeficiency Disease | |||
| National Institute of Allergy and Infectious Diseases Extramural Activities(NIAID) | 1985 | ||
| Cross-reacting Antigens On Spermatozoa And Cancer Cells | |||
| National Cancer Institute(NCI) | 1981 - 1983 | ||
Publications
| 1. Anderson DJ, Yunis EJ. "Trojan Horse" leukocytes in Acquired Immunodeficiency Syndrome (AIDS). N Eng J Med. 1983; 309:984.
2. Wolff H, Anderson DJ. Male genital tract inflammation is associated with increased numbers of potential HIV host cells in semen. Andrologia 1988; 20:404-410. 3. Anderson DJ, Politch JA, Martinez A, VanVoorhis BJ, Padian NS, O'Brien TR. White blood cells and HIV-1 in semen from vasectomized seropositive men. Lancet 1991; 338:573-574. 4. Pudney J, Anderson DJ. Orchitis and HIV-1 infected cells in reproductive tissues from men with the Acquired Immune Deficiency Syndrome. Am J Pathol; 1991; 139:149-160. 5. Anderson DJ, O'Brien TR, Politch JA. et al. Effects of disease stage and zidovudine therapy on the detection of HIV-1 in semen. JAMA 1992; 267:2769-2774. 6. Hill JA, Anderson DJ. Human vaginal leukocytes and the effects of vaginal fluid on lymphocyte and macrophage defense functions. Am J Obstet Gynecol 1992; 166:720-726. 7. Pudney J, Oneta M, Mayer K, Seage G, Anderson DJ. Pre-ejaculatory fluid is a potential vector for the sexual transmission of HIV-1. Lancet 1992; 340:1470-1471. 8. Anderson DJ, Abbott AF, Jack RA. The role of the complement component C3b and its receptors in sperm-oocyte interaction. PNAS. 1993; 90:10051-10055. 9. Hill JA, Polgar K, Anderson DJ. T helper 1-type cellular immunity to trophoblast antigens in women with recurrent spontaneous abortion. JAMA 1995; 273:1933-1936. 10. Pudney J, Anderson DJ. Immunobiology of the human penile urethra. Am J Path 1995, 147:155-65. 11. Rasmussen SJ, Eckmann L, Quayle AJ, Anderson DJ, Fierer J, Kagnoff MF. Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in Chlamydial pathogenesis. JCI 1997;99:77-87. 12. Gipson IK, Ho SB, Spurr-Michaud SJ, Tisdsale AS, Zhan Q, Torlakovic E, Pudney J, Anderson DJ, Toribara NW, Hill JA. Mucin genes expressed by human female reproductive tract epithelia. Biol Reprod 1997; 56:4:999-1011. 13. Quayle AJ, Xu C, Mayer KH, Anderson DJ. T lymphocytes and macrophages, but not motile spermatozoa, are a signficant source of HIV in semen. J Infect. Dis. 1997; 176:960-8. 14. Fichorova RN, Rheinwald JG, Anderson DJ. Generation of papillomavirus-immortalized cell lines from normal human ectocervical, endocervical and vaginal epithelium that maintain expression of tissue-specific differentiation proteins. Biol Reprod 1997;57, 847-855. 15. Xu C, Politch JA, Tucker L, Mayer KH, Seage GR, Anderson DJ. Risk factors associated with increased levels of HIV-1 DNA in semen. J Infect. Dis 1997; 174:941-7. 16. Quayle AJ, Coston WM, Kalams S, Mayer KH, Anderson DJ. Detection of HIV-1 specific cytotoxic T cells in semen from HIV-infected individuals. J Immunol 1998,161:4406-4410. 17. Holodniy M, Anderson DJ, Wright D Sharma O, Cohn J, Alexander N, Stratton P, Reichelderfer P. Quantification of HIV-1 in vaginocervical secretions: lack of inhibitory effect of menstrual cycle fluids. J Virol Meth 1998; 185-195. 18. Anderson DJ, Politch JA, Tucker LD, Fichorova R, Haimovici F, Tuomala RE, Mayer KH. Quantitation of mediators of inflammation and immunity in genital tract secretions and their relevance to HIV type 1 transmission. AIDS Research and Human Retroviruses. 1998; 14, suppl. 1. 19. Vassiliadou N, Anderson DJ. Progesterone-induced inhibition of chemokine receptor expression on blood mononuclear cells correlates with reduced HIV-1 infectibility in vitro. JI 1999;162:7510-7518. 20. Mayer K, Boswell S, Goldstein R, Wo L, Xu C, Tucker L, DePasquale M, D’Aquila R, Anderson DJ. HIV persistence in semen after adding indinavir to combination antiretroviral therapy. CID 1999;28:1252-1259. 21. Panther, LA, Tucker, L, Xu, C, Tuomala, RE, Mullins, JI, and Anderson, DJ. Genital tract Human Immunodeficiency virus type 1 (HIV-1) shedding and inflammation and HIV env diversity in perinatal HIV-1 transmission. J. Infect. Dis. 181:555-563, 2000. 22. Cu-Uvin S, Wright D, Anderson DJ, Reichelderfer P. Hormonal levels among HIV-seropositive women compared to high risk HIV-seronegative women during the menstrual cycle. J Wom Health 2000; 9:857-863. 23. Al-Harthi L, Wright DJ, Anderson DJ, et al. The impact of the ovulatory cycle on cytokine production: Evaluation of systemic, cervicovaginal and salivary compartments. J. Int Cytokine Res 2000; 20:719-724. 24. Fichorova R, Tucker L, Anderson DJ. The molecular basis of Nonoxynol-9-induced vaginal inflammation and its possible relevance to Human Immunodeficiency Virus-1 Transmission. J Inf. Dis 2001; 184:418-28. 25. Fichorova R, Cronin AO, Lien E, Anderson DJ, Ingalls RR. Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling. J. Immunol. 2002; 168:2424-2437. 26. Tuomala RE, O’Driscoll PT, Bremer JW, …Anderson DJ. Cell-associated genital tract virus and vertical transmission of HIV-1 in antiretroviral-experienced women. J Inf Dis 2003;187:375-84. 27. Wang XC, Anderson DJ., Yunis EJ, Hill JA Il-B polymorphism associated with TH1 immunity in recurrent miscarriage. Genes and Immunity 2002; 3:38-42. 28. Gardiulo A, Fichorova RN, Politch J, Hill JA, Anderson DJ. Detection of implantation-related cytokines in cervicovaginal secretions and peripheral blood of fertile women during ovulatory menstrual cycles. Fert Steril 2004; 82: 1226-34. 29. Fawzi W, Msamanga G, Antelman G, Xu C, Hertzmark E, Spiegelman D, Hunter D, Anderson D. Effect of prenatal vitamin supplementation on lower genital levels of HIV-1 and Il-1B at 36 weeks of gestation. Clin Inf Dis 2004; 38: 716-722. 30. Anderson DJ, Pudney J. Mucosal Immunology of the human male genital tract and experimental models. In: Mucosal Immunology, 3rd Edition, J Mestecky, M Lamm, W Strober, J Bienenstock, JR McGhee, L Mayer, eds. Elsevier Acad Press, pub. 2005; pp 1647-1660. 31. Pudney J, Quayle A and Anderson DJ. Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone. BOR 2005; 73:1253-63. 32. Xu C, Politch JA, Mayer KH, Anderson DJ. Human Immunodeficiency Virus Type 1 episomal cDNA in semen. AIDS Res Ther 2005; 2:9. 33. Anderson DJ. Immunology in the Era of HIV/AIDS. In: The AIDS Pandemic. K. Mayer and H. Pizer, eds Elsevier Academic Press, San Diego, CA.2005; pp 36-57. 34. Anderson DJ. HIV and AIDS. Our Bodies Ourselves. Simon and Schuster, pub. 2005; pp 291-306. 35. Ayehunie S, Cannon C, Lamore S, Kubilus J, Anderson D, Pudney J, Klausner M. Organotypic human vaginal-ectocervical tissue model for irritation studies of spermicides, microbicides and feminine-care products. Toxicology in Vitro 2006; 20:689-98. 36. Cone RA, Hoen T, Wong X, Abusuwwa R, Anderson DJ, Moench TR. Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission. BMC Infectious Diseases 2006, 6:90. 37. Wang ZC, Hill JA, Yunis EJ, Xiao L, Anderson DJ. Maternal CD46H*2 and IL1B-511*1 homozygosity in T helper 1-type immunity to trophoblast antigens in recurrent pregnancy loss. Human Reproduction 2006; 21: 818-22. 38. Quayle AJ, Kourtis AP, Cu-Uvin S, Politch JA, Yang H, Bowman FP, Shah M, Anderson D, Crowley-Nowick P, Duerr A. T-lymphocyte profile and total and virus-specific immunoglobulin concentrations in the cervix of human immunodeficiency virus-1-infected women. JAIDS 2007; 44:292-298 39. Kupka R, Msamanga GI, Xu C, Anderson D, Hunter D and Fawzi WW. Relationship between plasma selenium concentrations and lower genital tract levels of HIV-1 RNA and interleukin type 1 beta. Eur J Clin Nutr. 2007; 61: 542-7. 40. Bezold G, Politch JA, Kiviat NB, Kuypers JM, Wolff H, Anderson DJ. Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia. Fertil Steril 2007; 87: 1087-97. 41. Shrivastava MD, Anderson DJ. Progesterone receptor expression by human leukocyte cell lines: molecular mechanisms of cytokine expression. Clin Exp Obstet Gynecol 2007; 34: 14-24. 42. Anderson DJ. Innate and acquired immunity of the human genital tract. In: Sexually Transmitted Diseases, 4th edition. KK Holmes et al, eds. (2007) 43. Politch JA, Tucker L, Bowman FP, Anderson DJ. Concentrations and significance of cytokines and other immunologic factors in semen of healthy fertile men. Human Reproduction 2007. |
Patents
Search USPTO for Deborah J Anderson Patents