RCID: 654767
Link to this profile: http://www.researchcrossroads.org/Researchers/654767
Peter V Hornbeck
CELL SIGNALING TECHNOLOGY, INC.| Website Degrees PhD, University of California San Francisco BA, University of California Berkeley Interests cell biology protein structure post-translational modifications signaling networks protein phosphorylation bioinformatics protein motifs All Funding $ 2,424,449 |  |
Biography
| 1999-Senior Scientist, Cell Signaling Technology, Inc.
1999 Consultant, New England Biolabs 1996-99 Founder and President, Phosphoprotein Databases Inc. 1989-96 Adjunct Assistant Professor, Molecular and Cellular Biology, University of Maryland School of Medicine 1989-96 Assistant Professor of Medicine, Division of Rheumatology and Clinical Immunology,University of Maryland School of Medicine 1984-89 Postdoctoral Fellow, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda 1979-84 Research Associate, Department of Microbiology and Immunology, University of California San Francisco 1971-78 Research Associate, Department of Biochemistry, University of California Berkeley |
Grants (Principal Investigator)
Grants for which Peter V Hornbeck acted as the principal investigator
| Title/Granting Organization | Fiscal Years | Total Funding | |
|---|---|---|---|
| Phosphosite. And The Phosphoproteome Of Cancer | |||
| National Cancer Institute(NCI) | 2006 - 2009 | $ 712,703 | |
| Development Of A Protein Phosphorylation Site Database | |||
| National Institute on Alcohol Abuse and Alcoholism(NIAAA) | 2002 - 2004 | $ 1,306,440 | |
| Functional Cell Biology Of Phosphomyristin C | |||
| National Institute of Allergy and Infectious Diseases Extramural Activities(NIAID) | 1993 - 1995 | $ 306,841 | |
| Funtional Cell Biology Of Phosphomyristin C | |||
| National Institute of Allergy and Infectious Diseases Extramural Activities(NIAID) | 1992 | $ 98,465 | |
Publications
| 1. Hornbeck PV, Lewis GK. Idiotypic connectance in the immune system. I. Expression of a cross reactive idiotope on induced anti-p-azophenyl-arsonate antibodies and on endogenous antibodies not specific for arsonate. J Exp Med 1983; 157:1116-1137.
2. Hornbeck PV, Wilson AC. Local effects of amino acid substitutions on the active site region of lysozyme: A comparison of physical and immunological results. Biochemistry 1984; 23:998-100. 3. Hornbeck PV, Lewis GK. Idiotypic connectance in the immune system. II. A heavy chain variable region idiotope which dominates the antibody response to the p-azobenzene-arsonate group is a minor idiotope in the response to the trinitrophenyl group. J Exp Med 1985; 161:53-71. 4. Hornbeck PV, Paul WE .: Anti-immunoglobulin and phorbol ester induces phosphorylation of proteins associated with the plasma membrane and cytoskeleton in murine B lymphocytes. J Bio Chem 1986; 261:14817-14824. 5. Hornbeck PV, Huang KP, Paul WE. Lamin B is rapidly phosphorylated in lymphocytes following activation of protein kinase C. Proc Natl Acad Sci USA 1988; 85: 2279-2283. 6. Hornbeck PV, Nakabayashi H, Fowlkes BJ, Paul WE, Kligman D. A major myristylated substrate of protein kinase C and protein kinase C itself are differentially regulated during murine B and T lymphocyte development and activation. Mol Cell Biol 1989; 9:3727-3735 7. Hornbeck PV, Enzyme linked immunosorbent assays. In Ausubel FM, Brent R, Moore DD, Seidman JG, Smith JA, Struhl K, eds. “Current Protocols in Molecular Biology”. Green Publishing Associates, 1991: 2.1.2-2.1.20. 8. Berg W, Hornbeck PV. A micro radioimmunoassay for the measurement of intracellular cAMP. BioTechniques 1993; 15:56-59. 9. Hornbeck PV, Garrels JI, Capetanaki Y, Heimer S. Vimentin expression is differentially regulated by IL-2 and IL-4 in murine T cells. J Immunol 1993; 151:4013-4021. 10. Sieckmann DG, Holmes K, Hornbeck PV, Martin E, Guelde G, Bondada S, Longo DL, Kenny JJ. B cells from M167 µk transgenic mice fail to proliferate after stimulation with soluble anti-Ig antibodies: a model for antigen-induced B cell anergy. J Immunol 1994; 152:4873-4883. 11. Yi A-K, Hornbeck P, Lafrenz DE, Krieg AM. CpGDNA rescue of murine B lymphoma cells from anti-IgM induced growth arrest and programmed cell death is associated with increased expressions of c myc and bcl-XL, J Immunol, 1996; 157:4918-4925. 12. Lemkin PF, Myrick JM,Lakshmanan Y, Shue MJ, Patrick JL, Hornbeck PV, ThornwalGC, Partin AW. Exploratory data analysis groupware for qualitative and quantitative electrophoretic gel analysis over the Internet – WebGel. Electrophoresis, 1999; 20:3492-507. 13. Hui Zhang H, Zha X, Tan Y, Hornbeck P, Mastrangelo AJ, Alessi D, Polakiewicz R, and Comb MJ. Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs. J Biol Chem. 2002 Oct 18;277(42):39379-87. 14. Hornbeck PV, Chabra I, Kornhauser JM, Skrzypek E, Zhang B. PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylation. .Proteomics. 2004 Jun;4(6):1551-61. |
Patents
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